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Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma
1Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy.
British Journal of Cancer
|February 23, 1999
Abstract:
Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that angiogenesis parallels progression of MM, and that MCs participate in its induction via angiogenic factors in their secretory granules.