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NMR screening in drug discovery.
1Vertex Pharmaceuticals Incorporated 130 Waverly Street Cambridge MA 02139-4242 USA. moore@vpharm.com
Current Opinion in Biotechnology
|February 27, 1999
Summary
Nuclear Magnetic Resonance (NMR) is shifting from structural analysis to identifying drug ligands. This enables faster screening and design of potential drug molecules for protein targets.
Area of Science:
- Biochemistry
- Medicinal Chemistry
- Structural Biology
Background:
- Nuclear Magnetic Resonance (NMR) spectroscopy traditionally aids in determining the structure of drug targets and their complexes with ligands.
- Recent advancements indicate a paradigm shift in NMR applications within drug discovery.
Purpose of the Study:
- To highlight the evolving role of NMR in drug discovery.
- To emphasize the transition from structural characterization to ligand identification and screening.
Main Methods:
- Utilizing NMR spectroscopy for high-throughput screening of potential drug candidates.
- Applying NMR techniques to identify ligands that bind to protein targets.
Main Results:
- NMR is emerging as a powerful tool for identifying novel ligands.
- The focus in NMR laboratories is increasingly on screening and drug design.
Conclusions:
- NMR offers a viable alternative approach for ligand identification in drug discovery.
- This shift enhances the efficiency of discovering and designing potential drug molecules.