Related Experiment Videos
Synthesis of new thiolated acyclonucleosides with potential anti-HBV activity
I F Zeid1, A A Abdel-Rahman, A E Abdel-Megied
1Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt.
Nucleosides & Nucleotides
|February 27, 1999
Abstract:
Treatment of the sodium salt of compounds 1, 7 or 12 with chloroethyl methyl ether, 2-chloroethyl toluoylate or 2-(2-chloro ethoxy)ethyl acetate afforded the corresponding derivatives 2, 3, 4, 8, 9, 13 and 14. Ammonolysis of 3, 4, 9 and 14 at room temperature gave the corresponding hydroxyalkyl derivatives 5, 6, 10, 11, and 15, respectively. Alkylation of 2,4-dithiouracil gave 2,4-dialkylthio pyrimidine.