Therapy-related myelodysplastic syndrome in adults with neurofibromatosis
C Papageorgio1, K Seiter, E J Feldman
1Zalmen A. Arlin Cancer Institute and Department of Medicine, New York Medical College, Valhalla, 10595, USA.
Leukemia & Lymphoma
|February 27, 1999
Abstract:
Although an increased risk of hematologic malignancies in children with Neurofibromatosis-1 (NF-1) is well established, whether adults with NF-1 have an increased risk of such malignancies is unclear. We currently describe two adult patients with NF-1 who rapidly developed secondary myelodysplastic syndromes with abnormalities of chromosome 7 following chemotherapy for AML. We propose that adults with NF-1 also have abnormalities of hematologic progenitor cells.


