Ischemic nephropathy: diagnosis and treatment

Recent epidemiologic studies have shown that ischemic nephropathy secondary to stenosis or obstruction of the main renal arteries in the cause of renal insufficiency in a growing number of subjects. The clinicians dealing with renovascular disease need non-invasive diagnostic tools and effective therapeutic measures to successfully face the problem. Duplex ultrasound scanning is a non-invasive, non expensive diagnostic tool and when an experienced, dedicated technologist is available, it should be suggested as the first-step test. Magnetic resonance angiography and spiral CT angiography play an ancillary role in detecting patients with renovascular disease. Captopril-enhanced (CE) scintigraphy when positive indicates the activation of intrarenal renin-angiotensin system and may be useful in detecting patients with renal artery stenosis. Moreover, CE scintigraphy can play an important role in the choice between the revascularization and a wait-and-see approach. As a matter of fact, the presence of an activated intrarenal renin-angiotensin system furnishes theoretical as well practical reasons in favour of the revascularization. In the recent years percutaneous transluminal renal angioplasty has become the cornerstone of therapeutic strategy. The introduction of the metallic stent has dramatically improved its efficacy in ostial stenoses and has reduced the indication for surgical revascularization.