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Ketolide treatment of Haemophilus influenzae experimental pneumonia
K E Piper1, M S Rouse, J M Steckelberg
1Division of Infectious Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55902, USA.
Antimicrobial Agents and Chemotherapy
|February 27, 1999
Abstract:
The MICs of HMR 3004 and HMR 3647 at which 90% of beta-lactamase-producing Haemophilus influenzae isolates were inhibited were 4 and 2 micrograms/ml, respectively. Both HMR 3004 and HMR 3647 were active against beta-lactamase-producing H. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance of H. influenzae, HMR 3004 was more effective (P < 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or HMR 3647 in this model.