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A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
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A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s

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A novel cytochrome P450 3A isoenzyme in rat intestinal microsomes

G V Gushchin1, M I Gushchin, N Gerber

  • 1Department of Pharmacology, College of Medicine, Ohio State University, Columbus 43210, USA. ghennady.gushchin@vtmednet.org

Biochemical and Biophysical Research Communications
|March 2, 1999
PubMed

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Cytochrome P450 (CYP450) enzymes are a superfamily of heme-containing monooxygenases that play a pivotal role in Phase I drug metabolism by catalyzing oxidation and reduction reactions.These enzymes transform lipophilic xenobiotics into more hydrophilic metabolites, facilitating subsequent Phase II conjugation and eventual excretion. The CYP450 family is classified into families (e.g., CYP1–CYP3) and subfamilies (e.g., CYP2A, CYP2C), based on amino acid sequence homology.CYP450 isoenzymes,...