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Updated: Aug 7, 2026

Rapid Quantification of Mitogen-induced Blastogenesis in T Lymphocytes for Identifying Immunomodulatory Drugs
Published on: December 27, 2016
[The mutagenic and antimutagenic effects of immunomodulators]
Abstract:
In animal experiments (albino rats), stimulating and suppressive effects were studied of immunomodulating agents on the processes of chemical mutagenesis. Combination of different immunodepressants hardly ever intensifies cyclophosphamide-induced chromosomal rearrangement in rat bone marrow cells, with heparin exerting an antimutagenic effect, while corticosterone, when being administered at an augmented dose, appeared to enhance cyclophosphamide's mutagenic action. One-stage administration of immunostimulants and cyclophosphamide tended to weaken antimutagenic defence of cell genetic apparatus.
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