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Bcl-2 and p53 expressions in invasive bladder cancers
1Department of Pathology, College of Medicine, Hanyang University, Seoul, Korea. gkong@email.hanyang.ac.kr
Acta Oncologica (Stockholm, Sweden)
|March 2, 1999
Summary
p53 protein expression indicates a poor prognosis in both superficial and invasive bladder cancers. Bcl-2 protein overexpression is also linked to reduced survival in invasive bladder tumors and lower chemotherapy effectiveness.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Bladder cancer prognosis is influenced by various molecular markers.
- Understanding the role of p53 and Bcl-2 proteins is crucial for predicting patient outcomes.
Purpose of the Study:
- To investigate the prognostic value of p53 and Bcl-2 protein expression in bladder cancer patients.
- To assess the association of these proteins with tumor recurrence, progression, survival, and chemoeffectiveness.
Main Methods:
- Immunohistochemical analysis of p53 and Bcl-2 protein expression in 89 bladder cancer patients.
- Statistical analysis including survival analysis and multivariate analysis.
Main Results:
- p53-positive superficial tumors showed shorter recurrence and progression times.
- p53 and Bcl-2 overexpression were associated with lower survival rates in invasive tumors.
- Bcl-2-positive tumors had significantly lower response rates to chemotherapy.
Conclusions:
- p53 expression is an independent poor prognostic marker for both superficial and invasive bladder cancers.
- Bcl-2 overexpression is independently associated with reduced survival in invasive bladder cancer.
- Prognostic differences may relate to chemo- or radio-sensitivity and the apoptotic process.