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Comparison of healing process in open osteotomy model and closed fracture model
1The J. Vernon Luck, Sr., M.D., Orthopaedic Research Center, Los Angeles Orthopaedic Hospital, California 90007, USA.
Objective:
Comparison of the healing process in open osteotomy and closed fracture models that were used to study fracture healing.
Design:
Randomized, prospective study in experimental animals, with a recovery duration of two and four weeks.
Setting:
Unrestricted cage activity with weight bearing as tolerated.
Animals:
Thirty-four skeletally mature, female New Zealand White rabbits.
Interventions:
Closed fractures and open osteotomies of the tibial diaphysis were reduced and immobilized with four-pin, double-bar external fixators.
Main Outcome Measurements:
Callus circumference was measured with a tape measure, bridging callus was assessed on biplane radiographs and evaluated histologically, and torsional stiffness and maximum torque were measured.
Results:
Periosteum damage was more severe and hematoma formation was smaller in the osteotomy model, resulting in a delay in biological healing and restoration of the biomechanical properties.
Conclusions:
Investigators should consider the difference between the closed fracture and open osteotomy models when selecting an animal model to investigate fracture healing.