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Related Experiment Videos

Respiratory muscle involvement in multiple sclerosis.

R Gosselink1, L Kovacs, M Decramer

  • 1Respiratory Rehabilitation and Respiratory Division, University Hospitals, Katholieke Universiteit Leuven, Belgium.

The European Respiratory Journal
|March 5, 1999
PubMed
Summary
This summary is machine-generated.

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Respiratory muscle weakness is common in multiple sclerosis, affecting cough and potentially leading to respiratory failure. Training may help, but long-term benefits require further study.

Area of Science:

  • Neurology
  • Pulmonology
  • Rehabilitation Medicine

Background:

  • Respiratory complications are a major cause of mortality in advanced multiple sclerosis (MS).
  • Respiratory muscle weakness, particularly expiratory muscle weakness, is frequently observed in MS patients, even with normal pulmonary function.
  • This weakness can lead to ineffective coughing, increasing the risk of pneumonia and acute respiratory failure.

Purpose of the Study:

  • To investigate the relationship between respiratory muscle weakness and pulmonary function in multiple sclerosis (MS).
  • To explore the potential of respiratory muscle training as an intervention for MS patients.

Main Methods:

  • The study reviewed existing literature on respiratory complications, muscle function, and pulmonary tests in multiple sclerosis patients.

Related Experiment Videos

  • It analyzed the prevalence and characteristics of respiratory muscle weakness, distinguishing between inspiratory and expiratory muscles.
  • The potential impact of respiratory muscle training was considered based on recent research.

    • Main Results:

    • Respiratory muscle weakness is prevalent in MS and can occur early in the disease course.
    • A notable finding is the poor correlation between the degree of muscle weakness and overall pulmonary function.
    • Expiratory muscle weakness is more pronounced than inspiratory weakness, significantly impacting cough effectiveness.

    Conclusions:

    • Respiratory muscle weakness is a significant contributor to morbidity and mortality in multiple sclerosis, independent of general pulmonary function.
    • While respiratory muscle training shows promise for improving strength and endurance in MS patients, its long-term efficacy in preventing complications or improving survival is yet to be established.
    • Further research is needed to determine the clinical utility of respiratory muscle training in managing multiple sclerosis-related respiratory dysfunction.