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Related Experiment Videos

Cold exposure and immune function.

R J Shephard1, P N Shek

  • 1Faculty of Physical Education and Health, Department of Public Health Sciences, University of Toronto, Ontario, Canada. royjshep@mountain-inter.net

Canadian Journal of Physiology and Pharmacology
|March 5, 1999
PubMed
Summary
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Severe cold exposure acutely suppresses immune function in mammals, reducing key immune cells and responses. However, the immune system can adapt to cold over several weeks, though more research is needed for humans.

Area of Science:

  • Immunology
  • Environmental Physiology

Background:

  • Cold exposure is a significant environmental stressor.
  • Understanding its impact on the immune system is crucial for health and performance.

Purpose of the Study:

  • To review the influence of cold exposure on immune function.
  • To summarize current findings on immune responses to cold stress.

Main Methods:

  • Review of existing data, primarily from small mammal studies.
  • Analysis of effects on cellular and humoral immune components.

Main Results:

  • Acute severe chilling suppresses lymphocyte proliferation, immune cascade, natural killer (NK) cell count, and complement activation.
  • Heat shock proteins are induced by cold exposure.

Related Experiment Videos

  • Adaptation to cold stimulus occurs within 2-3 weeks.

    • Conclusions:

    • Cold exposure significantly impacts immune function, with acute suppression followed by adaptation.
    • Further research is required on cold exposure, exercise interactions, and human immunosurveillance.