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Synthesis and antiviral activity of novel aza-acyclonucleosides
S C Bergmeier1, S L Fundy, J C Drach
1Division of Medicinal Chemistry, Ohio State University, Columbus 43210-1290, USA.
Abstract:
We have prepared a series of novel aza-acyclonucleosides as potential antiviral agents. These compounds were prepared from diethanolamine and the desired purine or pyrimidine base via a Mitsunobu coupling. No antiviral activity was observed against either HSV-1 or HCMV.