Related Experiment Video
Updated: Sep 11, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
Published on: April 13, 2010
[Prophylaxis of immediate and delayed reactions in exogenic allergic bronchial asthma (author's transl)]
Abstract:
In 14 antigen provocation tests in 12 patients with allergic bronchial asthma, an immediate bronchoconstriction could be demonstrated by whole body plethysmography and a delayed reaction in 6 other cases. The examinations were repeated after a single prophylactic application of 40 mg disodium cromoglicate. By this means, 10 of the 14 immediate reactions and 4 of the 6 delayed reactions could be completely or largely prevented; in 4 and 2 patients respectively the protective effect was unsatisfactory. In longterm experiments over 4--6 months an improvement in the findings was recorded in 9 of the 12 patients. A rare side-effect of disodium cromologlicate therapy is irritation of the respiratory tract, in some cases with not inconsiderable respiratory obstruction.
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