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Oral wart associated with human papillomavirus type 2
M Terai1, M Takagi, T Matsukura
1Department of Pathology, AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Summary
Human papillomavirus type 2 (HPV-2) DNA was detected in an oral wart, a rare occurrence. This finding expands the known oral manifestations of HPV-2 infections.
Area of Science:
- Oral pathology
- Dermatology
- Virology
Background:
- Over 100 human papillomavirus (HPV) types are known.
- 24 HPV types are associated with oral lesions.
- HPV-2 is typically linked to skin lesions, with oral involvement rarely reported.
Observation:
- A biopsy of an oral wart from a 48-year-old man was analyzed.
- Histological examination revealed papillary epithelial growth, hyperkeratosis, parakeratosis, and koilocytotic changes.
- These features mimicked cutaneous verruca vulgaris.
Findings:
- Immunohistochemistry detected papillomavirus genus-specific capsid antigen in koilocytotic cells.
- Southern blot hybridization confirmed the presence of HPV-2 DNA in the lesion.
- In situ hybridization localized HPV-2 DNA to the nuclei of deeper epithelial cells than those positive for viral antigen.
Implications:
- This case demonstrates that HPV-2 can cause oral mucosal lesions.
- It highlights the importance of considering HPV-2 in the differential diagnosis of oral warts.
- Further research may clarify the pathogenesis and clinical significance of HPV-2 in oral infections.