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[Pharmacokinetics of beta blockers in hyperthyroidism. Therapeutic relevance]
1Laboratoire de Pharmacologie Toxicologie, Hôpital Maison-Blanche-CHU, Reims, France.
Abstract:
Hyperthyroidism is associated with alterations in pharmacokinetic parameters such as absorption, distribution, metabolism and elimination. Beta-blockers are used in particular in the treatment of hyperthyroidism and are also subject to pharmacokinetic changes occurring during this pathology. The magnitude of these variations is examined when beta-blockers are used for clinical manifestations of hyperthyroidism or during thyroid surgery. Clinical means used to assess the accuracy of therapeutic drug monitoring are also described.