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Comparison of four magnetic resonance methods for mapping small temperature changes.

W Wlodarczyk1, M Hentschel, P Wust

  • 1Clinic for Radiation Medicine, Charité Medical School-Campus Virchow-Klinikum, Berlin, Germany. waldemar.wlodarczyk@charite.de

Physics in Medicine and Biology
|March 10, 1999
PubMed
Summary

Non-invasive magnetic resonance (MR) thermography can detect small temperature changes for hyperthermia cancer treatment. The water proton resonance frequency (PRF) method showed the most promise for monitoring temperature shifts with high accuracy.

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Area of Science:

  • Medical Physics
  • Biomedical Engineering
  • Oncology

Background:

  • Accurate non-invasive temperature monitoring is crucial for advancing regional hyperthermia cancer treatment.
  • Magnetic resonance (MR) thermography offers a promising approach for detecting subtle temperature variations (< 1°C).

Purpose of the Study:

  • To evaluate four MR thermography methods for non-invasive detection of small temperature changes relevant to hyperthermia treatment.
  • To compare the sensitivity and accuracy of different temperature-dependent MR parameters.

Main Methods:

  • Four MR thermography methods were assessed using phantom experiments: spin-lattice relaxation time (T1), diffusion coefficient (D), water proton resonance frequency (PRF), and a praseodymium (Pr) complex probe.
  • Pulse sequences included TOMROP (T1), PGSE (D), FLASH with phase difference reconstruction (water PRF), and CSI (Pr probe).

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  • Calibration curves were generated, followed by the creation and verification of temperature change maps.

    • Main Results:

    • All four methods achieved temperature change uncertainties < 1°C during calibration (Pr probe: 0.11°C, water PRF: 0.22°C, D: 0.48°C, T1: 0.93°C).
    • Temperature maps showed slightly higher errors but remained within the 1°C range (water PRF: 0.41°C, D: 0.70°C, Pr probe: 0.97°C, T1: 1.06°C).
    • The Pr probe method demonstrated the highest sensitivity and accuracy, but spatial resolution limitations of the CSI sequence impacted its thermographic map performance.

    Conclusions:

    • The water proton resonance frequency (PRF) method is currently the most suitable for MR monitoring of small temperature changes during hyperthermia treatment due to its balance of accuracy and spatial resolution.
    • While the Pr probe is highly sensitive, its application in thermographic mapping requires improved sequence resolution.
    • MR thermography holds significant potential for precise temperature monitoring in hyperthermia therapy.