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Inhibitory constituents against HIV-1 protease from Agastache rugosa
Archives of Pharmacal Research
|March 11, 1999
Abstract:
Two diterpenoid compounds, agastanol (1) and agastaquinone (2), were isolated from the roots of Agastache rugosa (Labiatae). Compound 1 and 2 showed significant inhibitory effects against human immunodeficiency virus type 1 (HIV-1) protease activity with IC50 values of 360 and 87 microM, respectively.