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Coordination of cell growth with cell division
1MGH Cancer Center, Massachusetts General Hospital Building 149, 13th Street, Charlestown, Massachusetts 02129, USA. polymeni@helix.mgh.harvard.edu.
Current Opinion in Genetics & Development
|March 11, 1999
Summary
Cell growth must match cell division. This study suggests cell division activators are made sensitive to protein synthesis capacity, linking cell growth and division.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- Cell proliferation requires coordinated cell growth and division.
- The mechanisms linking cell mass increase with cell cycle progression are not fully understood.
Purpose of the Study:
- To investigate how cell growth is coupled to cell division.
- To explore the role of protein synthesis capacity in regulating cell division.
Main Methods:
- The study likely involved analyzing the synthesis rates of cell division activators.
- Investigating the sensitivity of these synthesis pathways to cellular protein production capacity.
Main Results:
- Evidence suggests that the synthesis of cell division activators is highly sensitive to the cell's protein synthesis machinery.
- This sensitivity may serve as a critical control point for coordinating cell growth and division.
Conclusions:
- Cellular protein synthesis capacity plays a key role in regulating the cell cycle.
- Making cell division activators sensitive to protein synthesis machinery is a potential mechanism for coupling cell growth to cell division.