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Evolution of the terminal complement genes: ancient and modern
1Department of Biological Sciences, De Montfort University, Leicester, UK.mhobart@dmu.ac.uk
Experimental and Clinical Immunogenetics
|March 11, 1999
Abstract:
The data on the structure and relationships of the TCC genes are reviewed and a model is presented for the processes of gene duplication by which the modern genes might have evolved. Data on variations of the overall gene numbers and relationships in modern species are also reviewed, together with the polymorphisms found in man. The apparent contradictions of lack of allelic association between markers and lack of direct evidence for recombination in the C6/C7 gene region is also discussed.