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[The relationship between prognosis, metastasis and microvessel quantity in invasive breast carcinoma]
Objective:
To determine the prognostic value and relationship of microvessel quantity (MVQ) with PCNA, c-erbB-2, nm23-H1 and Cathepsin D in invasive breast carcinoma.
Methods:
Immunohistochemical techniques (LSAB) were used to detect the expression of PCNA, c-erbB-2, nm23-H1, Cathepsin D and MVQ in 76 cases of invasive breast carcinoma.
Results:
The mean of MVQ was 57.82 +/- 22.22 in 76 cases of invasive breast carcinoma. The expression of Cathepsin D (cancer cells), c-erbB-2 and node positive were not related to MVQ. MVQ was positively correlated to expression of Cathepsin D (stroma cells), PCNA and distant metastasis (10 years), but negatively correlated to 5 year survival.
Conclusion:
MVQ was significantly correlated to distant metastasis and survival period in invasive breast carcinoma. MVQ may be an independant prognostic indicator.