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Effect of tripterine on collagen-induced arthritis in rats
1Department of Pharmacology, School of Pharmacy, Shanghai Medical University, China.
Aim:
To study the therapeutic effect of tripterine (Tri) on collagen-induced arthritis (CIA).
Methods:
Collagen type II (Col) 1.5 mg was injected intradermally to induce CIA in rats. Hind paw volumes of rats were measured with a water displacement method. The serum anti-collagen antibody was measured by an enzyme-linked immunosorbent assay. Delayed hypersensitivity was reflected by skin response to Col. Interleukin-1 (IL-1) and interleukin-2 (IL-2) activities were evaluated by [3H]TdR uptake. Joint was evaluated histologically.
Results:
Tri 15 and 30 mg.kg-1.d-1 given i.g. to rats 3 d after the first sign of arthritis reduced inflammatory swelling, suppressed humoral and skin response to Col, inhibited IL-2 and IL-1 production, reduced pathological progression of joint.
Conclusion:
Tri has a therapeutic effect on CIA.