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Preparation and dissolution property of ipriflavone solid dispersion
1Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China. ypli@server.shcnc.ac.cn
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|March 29, 2001
Summary
This study prepared ipriflavone (IP) solid dispersion using the solvent method. The resulting solid dispersion significantly enhanced IP dissolution, demonstrating the efficacy of this formulation strategy.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Ipriflavone (IP) is a synthetic isoflavone with potential therapeutic applications.
- Poor aqueous solubility often limits the bioavailability of IP.
- Solid dispersion is a promising technique to enhance the dissolution of poorly soluble drugs.
Purpose of the Study:
- To prepare and characterize ipriflavone (IP) solid dispersion.
- To evaluate the dissolution properties of the prepared IP solid dispersion.
- To investigate the impact of solid dispersion on IP's physical characteristics.
Main Methods:
- Solid dispersion of IP was prepared using the solvent method.
- Identification and characterization involved differential scanning calorimetry (DSC), X-ray diffraction (XRD), and infrared spectrophotometry (IR).
- Dissolution testing was performed using the paddle method in artificial gastric juice.
Main Results:
- The dissolution rate of IP solid dispersion (IP:povidone-k30 (PVP) at 1:8 ratio) in artificial gastric juice was 6.15 times higher than that of IP alone.
- DSC, XRD, and IR analyses showed significant changes in IP's physical form after dispersion, indicating successful formulation.
- The formulation demonstrated improved solubility and dissolution characteristics.
Conclusions:
- Solid dispersion formulation significantly enhances the dissolution of ipriflavone.
- The solvent method is effective for preparing IP solid dispersions with improved dissolution properties.
- This approach holds potential for improving the bioavailability of ipriflavone.
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