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Adrenoceptor agonists inhibit calcium-dependent potentials in rat stellate ganglion neurons
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|March 1, 1997
Abstract
Aim:
To study the effects of adrenoceptor agonists on the stellate ganglion neurons.
Methods:
Intracellular recordings were made from neurons of the isolated rat stellate ganglia.
Results:
Noradrenaline and clonidine (10-30 mumol.L-1) reversibly depressed 3 types of calcium-dependent potentials, namely, the action potential shoulder; the spike after-hyperpolarization; the Ca2+ spike evoked in Krebs' solution containing TTX and TEA and fast excitatory postsynaptic potential (f-EPSP).
Conclusion:
The adrenoceptor agonists inhibitied the 3 calcium-dependent potentials; f-EPSP was inhibited by reducing Ca2+ influx at presynaptic site in population of neurons.