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Related Experiment Videos

High-dose therapy for breast cancer.

C A Hudis1, P N Münster

  • 1Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Seminars in Oncology
|March 12, 1999
PubMed
Summary

High-dose chemotherapy with autologous stem cell support is frequently used for breast cancer, despite ongoing controversy and a lack of definitive study results. Further research is needed to clarify its role in treatment.

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Breast cancer research and treatment·2016

Area of Science:

  • Oncology
  • Hematology

Background:

  • High-dose chemotherapy with autologous stem cell support is a common treatment for breast cancer in the US.
  • It is used for both early-stage high-risk and metastatic disease, with curative or palliative intent.
  • Its widespread adoption precedes definitive results from large randomized trials.

Purpose of the Study:

  • To review the theoretical basis and clinical translation of high-dose therapy for breast cancer.
  • To examine current treatment approaches, available data, and ongoing research.
  • To address the controversy surrounding its use in the absence of conclusive evidence.

Main Methods:

  • Review of theoretical basis from preclinical data.
  • Analysis of pilot and phase I/II trial results.
  • Discussion of clinical application and existing data.

Main Results:

  • High-dose therapy is widely accepted but lacks robust evidence from large prospective studies.
  • The approach is based on preclinical data, expert opinion, and early-phase trials.
  • Controversy persists due to promising but not yet validated outcomes.

Conclusions:

  • The use of high-dose chemotherapy for breast cancer is promising but controversial.
  • Randomized clinical trials are essential to establish its efficacy and optimal role.
  • Future research should focus on clarifying its benefits and risks.

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