[The study of ICAM-1 expression after brain ischemia-reperfusion injury in rats]

Intercellular adhesion molecule-1 (ICAM-1) expression was studied with rat transient cerebral ischemic model. The results showed that the expression of ICAM-1 markedly increased after 1 h ischemia following 6 h reperfusion. Laser confocal microscope demonstrated that the FITC quantum on blood vessels after reperfusion was more than 47% compared to that of pure ischemia. MPO activity and light microscope observation showed that leukocytes accumulated in injured tissue 9 h after reperfusion. The local IL-1 content in brain tissue changed with different period of reperfusion time. Our data indicated that after brain ischemia-reperfusion injury ICAM-1 expression was in time-dependent increase, the local IL-1 secretion might up regulate the ICAM-1 expression, there were large amount of leukocytes accumulated in surrounding tissue, the increase of ICAM-1 expression was the prerequisite for leukocyte adhesion and migration.