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Seven novel macrocyclic polypeptides from Viola arvensis.

U Göransson1, T Luijendijk, S Johansson

  • 1Division of Pharmacognosy, Department of Pharmacy, Biomedical Center, Uppsala University, Box 579, S-751 23 Uppsala, Sweden.

Journal of Natural Products
|March 17, 1999
PubMed
Summary

Seven new macrocyclic polypeptides, varv peptides B-H, were discovered in Viola arvensis. These peptides show high structural similarity to previously identified cyclic peptides.

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Area of Science:

  • Natural Product Chemistry
  • Peptide Chemistry
  • Plant Biochemistry

Background:

  • Macrocyclic peptides are a diverse class of natural products with unique structural features.
  • Viola species are known sources of bioactive compounds, including peptides.

Purpose of the Study:

  • To isolate and characterize novel macrocyclic polypeptides from Viola arvensis.
  • To elucidate the primary structures and investigate the homology of these new compounds.

Main Methods:

  • Isolation of peptides from aerial parts of Viola arvensis.
  • Structure elucidation using automated Edman degradation and mass spectrometry.
  • Sequence analysis and comparison with known macrocyclic peptides.

Main Results:

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  • Seven novel macrocyclic polypeptides, varv peptides B-H, were identified.
  • These peptides comprise 29 or 30 amino acid residues with cyclic amide backbones and three disulfide bridges.
  • Varv peptides B-H display significant sequence homology with known cyclic peptides like varv peptide A and kalata B1.

Conclusions:

  • The discovery of varv peptides B-H expands the known repertoire of macrocyclic peptides from Viola species.
  • The high degree of homology suggests a conserved structural motif and potentially related biosynthetic pathways among these cyclic peptides.