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07:09
Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
Influence of obesity on immune function
D C Nieman1, D A Henson, S L Nehlsen-Cannarella
1Department of Health and Exercise Science, Appalachian State University, Boone, NC 28608, USA.
Journal of the American Dietetic Association
|March 17, 1999
Summary
Obesity alters immune function, increasing some cell counts and phagocytosis while suppressing lymphocyte proliferation. This immune dysregulation may explain the higher infection risk in obese individuals.
Area of Science:
- Immunology
- Obesity Research
- Public Health
Background:
- Obesity is a growing public health concern linked to various health issues.
- Immune system function may be compromised in obese individuals, potentially increasing susceptibility to infections.
Purpose of the Study:
- To compare immune function between obese and nonobese women.
- To investigate the influence of aerobic fitness, psychological well-being, and metabolic factors on immunity in obesity.
Main Methods:
- Cross-sectional comparison of 116 obese and 41 nonobese women.
- Measurement of immune cell counts, lymphocyte proliferation, and phagocytic activity.
- Multiple regression analysis to assess the impact of obesity and other factors on immune parameters.
Main Results:
- Obesity associated with increased leukocyte and lymphocyte counts (excluding NK and T cells).
- Suppressed mitogen-induced lymphocyte proliferation observed in obese subjects.
- Enhanced monocyte and granulocyte phagocytosis and oxidative burst activity in obesity.
Conclusions:
- Obesity is demonstrably linked to significant alterations in immune system function.
- Further research is warranted to establish a clear link between obesity-induced immunosuppression and increased infection risk.
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