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Updated: Jul 29, 2026

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
Published on: August 3, 2011
Delayed repair of skin cancer defects
Purpose:
A review of surgical outcomes in 280 patients who underwent in-office excision of skin lesions, open wound therapy, and delayed reconstruction is presented. Advantages of open wound therapy and delayed reconstruction are discussed.
Patients And Methods:
The surgical records of all patients treated between January 1, 1994 and December 31, 1996 were evaluated for outcome and complications.
Results:
One hundred seventeen patients presented with biopsy-confirmed malignant skin lesions of the head and neck. After surgical excision of the malignancy, the wounds were treated with a semiocclusive dressing while waiting for the results of the biopsy report and reconstruction (open wound therapy). Eighty-nine percent of the residual skin defects were repaired within 10 days. The remaining 11% were closed within 35 days. Except for one allergic reaction to neomycin and slight blood oozing from the wound in two patients, no other complications occurred.
Conclusions:
Open wound therapy is an effective method for managing skin defects after excision of malignant lesions. It is cost-effective and can be done quickly as an in-office procedure under local anesthesia without complications.
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