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Antiangiogenic activity of tumor necrosis factor-alpha production regulators derived from thalidomide
R Shimazawa1, H Miyachi, H Takayama
1Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Biological & Pharmaceutical Bulletin
|March 17, 1999
Abstract:
Recently, we developed novel tumor necrosis factor (TNF)-alpha production regulators with a phthalimide skeleton derived from thalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenesis assay.