Synthesis of biologically active bis-[4-amino-5-mercapto-1,2,4- triazol-3yl]-alkanes and their derivatives

The preparation of bis-(4-amino-5-mercapto-1,2,4-triazol-3yl)alkanes is described. These bis-(amino-mercapto-triazolyl) alkanes are characterized by analytical and spectral data. They are also characterized by the preparation of the Schiff bases by condensing them with various benzaldehydes and nitro furfural diacetate in dimethyl formamide-ethanol medium in the presence of concentrated sulphuric acid. The structures of Schiff bases are assigned based on analytical and spectral data. The newly synthesized compounds are screened for their antibacterial properties against Gram-positive and Gram-negative bacteria. Most of them showed significant activity.