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Intracellular determinants of picornavirus replication
R Andino1, N Böddeker, D Silvera
1Dept of Microbiology and Immunology, University of California, San Francisco 94143-0414, USA. pandino@itsa.ucsf.edu
Trends in Microbiology
|March 19, 1999
Summary
Viral tissue tropism is determined by host factors beyond receptors. Intracellular proteins influencing picornavirus replication may dictate infection outcomes in specific cell types, though in vivo roles require further study.
Area of Science:
- Virology
- Molecular Biology
- Cell Biology
Background:
- Viruses exhibit restricted host and tissue tropism.
- Tissue tropism is influenced by viral receptors and intracellular host factors.
- Picornavirus replication involves numerous host proteins, but their in vivo functions remain largely unelucidated.
Purpose of the Study:
- To explore the potential role of intracellular proteins in determining picornavirus cell-type tropism.
- To investigate how these proteins might influence the pathogenic outcomes of picornavirus infections.
Main Methods:
- Analysis of host protein involvement in picornavirus translation.
- Investigation of host protein roles in picornavirus RNA replication.
- In vivo studies to establish the functional significance of these proteins (pending).
Main Results:
- Several intracellular proteins have been identified as potentially involved in picornavirus translation and RNA replication.
- These proteins are hypothesized to play a role in cell-type specific tropism.
Conclusions:
- Intracellular host factors, particularly proteins involved in viral replication, are likely critical determinants of picornavirus tissue tropism.
- Understanding these interactions is essential for predicting and potentially controlling picornavirus pathogenesis.