Recent advances in identifying and validating drug targets in trypanosomes and leishmanias
M P Barrett1, J C Mottram, G H Coombs
1Division of Infection & Immunity, University of Glasgow, UK.
Trends in Microbiology
|March 19, 1999
Abstract:
The unique aspects of the biochemistry of trypanosomatids make rational drug design an attractive approach, but targets must be selected carefully. Genetic manipulation provides a valuable means of mimicking loss of function attributable to therapeutic intervention, but caution must be exercised when interpreting such data with respect to target validation.
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