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Tissue engineering.

M V Sefton¹, K A Woodhouse

¹Department of Chemical Engineering and Applied Chemistry and Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

Journal of Cutaneous Medicine and Surgery

|March 19, 1999

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Tissue engineering innovations offer advanced wound care solutions, including synthetic dressings and biological skin substitutes. These technologies aim to improve healing, reduce scarring, and restore natural skin characteristics.

Area of Science:

Biomaterials Science
Regenerative Medicine
Tissue Engineering

Background:

Tissue engineering is revolutionizing wound care by developing novel materials for biological tissue interaction.
Current applications range from simple polymeric wound dressings to complex dermal replacements and skin substitutes.

Purpose of the Study:

To explore the role and advancements of tissue engineering in modern wound care.
To describe the spectrum of engineered materials used for wound management.

Main Methods:

Utilizing naturally occurring tissues and cells, or combining synthetics (polymers) with biological layers.
Developing materials with varying complexity based on specific end-use requirements in wound healing.

Main Results:

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Synthetic polymeric materials like Tegaderm and Opsite serve as protective wound dressings for shallow wounds.
Advanced products such as Integra(R) and Apligraf(R) offer dermal replacement and complete skin substitution, incorporating collagen and cells.

Conclusions:

Engineered skin substitutes are progressing towards fully functional replacements that modulate healing.
The ultimate goal is wound closure with minimal scarring, preserving natural skin characteristics through advanced tissue engineering.