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Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: Jul 6, 2026

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
09:50

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

Published on: February 11, 2019

Adult Cutaneous Chronic Graft-Versus-Host Disease: An In-Depth Review.

Arafat Atique1, Meghan Kanou1, Elena Netchiporouk2,3

  • 1Faculty of Medicine and Health Sciences, Université de Montréal, QC, Canada.

Journal of Cutaneous Medicine and Surgery
|July 4, 2026
PubMed
Summary
This summary is machine-generated.

Cutaneous chronic graft-versus-host disease (cGVHD) impacts many patients post-transplant, causing skin issues. New targeted therapies offer improved management, but further research is needed for better long-term outcomes.

Keywords:
cutaneous chronic graft-versus-host disease (cGVHD)delgocitinib creamfibrosisgenital skin diseasehematopoietic cell transplantation (HCT)immunopathogenesislichen sclerosustargeted therapiestopical JAK inhibitor therapy

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Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
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Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Related Experiment Videos

Last Updated: Jul 6, 2026

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
09:50

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

Published on: February 11, 2019

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
10:29

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Area of Science:

  • Immunology
  • Dermatology
  • Hematology

Background:

  • Cutaneous chronic graft-versus-host disease (cGVHD) is a common complication following allogeneic hematopoietic cell transplantation.
  • Skin manifestations in cGVHD can be severe, causing pain, functional impairment, and decreased quality of life.

Purpose of the Study:

  • To review current knowledge on the immunopathogenesis, clinical presentation, diagnosis, and management of cGVHD.
  • To highlight recent therapeutic advancements and emerging strategies for cGVHD treatment.

Main Methods:

  • Literature review of immunopathogenesis, clinical presentation, diagnostic tools, and management strategies for cGVHD.
  • Summary of current first-line therapies, novel agents, and future treatment directions.

Main Results:

  • Systemic corticosteroids are first-line but have variable efficacy and toxicity.
  • New agents (ibrutinib, ruxolitinib, belumosudil, axatilimab) targeting immune and fibrotic pathways show promise.
  • Relapse and treatment resistance remain challenges, necessitating further research.

Conclusions:

  • Individualized, mechanism-based treatments are crucial for managing heterogeneous cGVHD.
  • Advances in assessment tools (scoring systems, imaging, patient-reported outcomes) aid disease management.
  • Ongoing research into immune dysregulation and fibrosis aims to improve long-term patient outcomes.