[Inflammatory granulomas of fungal origin]

This trial on the histopathology of fungal granulomas was aimed at showing that fungi are good models for examination of variations in cellular participation in the inflammatory reactions which they provoke. Their presence stimulates activity of the entire leucocyte series and their tissular differentiations. They clearly demonstrate the association of capture phenomena with the polynuclears and macrophages as well as the humoral phenomena of immunity with the lympho-plasmocytes. Changes in the histiocytes are particularly remarkable in the mycoses and whilst the epithelioid cell found within tuberculoid structures seems, at least in part, to reflect a cutaneous hypersensitivity, the Virchow state corresponds to inhibition of the usual functions of lysis of pathogenic agents, resulting by contrast in undefined, intracellular multiplication of this agent, when cellular immunity cannot develop or has disappeared.