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Related Experiment Videos

The hepoxilins. A review.

C R Pace-Asciak1, D Reynaud, P Demin

  • 1Research Institute, Hospital for Sick Children, Toronto, Canada. pace@sickkids.on.ca

Advances in Experimental Medicine and Biology
|March 23, 1999
PubMed
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Hepoxilins release calcium from intracellular stores via a G-protein coupled receptor. Their omega-oxidation occurs in mitochondria, influencing calcium accumulation and inflammatory mediator actions.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Pharmacology

Background:

  • Hepoxilins are signaling lipids with diverse biological actions.
  • Their role in calcium homeostasis and inflammatory processes is under investigation.

Purpose of the Study:

  • To review current literature on hepoxilins, including their structure, biosynthesis, metabolism, and biological activities.
  • To present novel data on hepoxilin catabolism and its implications.

Main Methods:

  • Literature review of hepoxilin research.
  • Presentation of unpublished experimental data on hepoxilin metabolism.
  • Analysis of hepoxilin analog activity.

Main Results:

  • Hepoxilins release intracellular calcium via an intracellular, G-protein coupled receptor.

Related Experiment Videos

  • Hepoxilin omega-oxidation is mediated by a distinct enzyme, sensitive to cell disruption and mitochondrial uncouplers.
  • Hepoxilin analogs inhibit calcium release by neutrophil inflammatory mediators.

    • Conclusions:

    • Hepoxilin metabolism and calcium signaling are closely linked, potentially involving mitochondrial pathways.
    • Hepoxilins and their analogs represent potential therapeutic targets for inflammatory conditions.