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Related Experiment Videos

Parallel information processing in the dorsal striatum: relation to hippocampal function.

B D Devan1, N M White

  • 1Department of Psychology, McGill University, Montreal, Quebec, Canada H3A 1B1.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|March 23, 1999
PubMed
Summary
This summary is machine-generated.

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Lesions in the brain

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Animal Behavior

Background:

  • The brain's ability to navigate and learn spatial information is crucial for survival.
  • Understanding the neural mechanisms underlying spatial memory and cue-based learning is essential.

Purpose of the Study:

  • To investigate the distinct roles of the lateral and medial caudate putamen (CPu) and the fornix/fimbria in spatial learning and cue-dependent behavior.
  • To determine how lesions in these brain regions affect rats' performance in a water maze task that dissociates spatial and cue-based information.

Main Methods:

  • Rats underwent concurrent training on cue (visible platform) and spatial (submerged platform) tasks in a water maze.
  • Lesions were made in the lateral CPu, medial CPu, and fornix/fimbria.

Related Experiment Videos

  • A competition test assessed response tendencies between cue and spatial information.

    • Main Results:

    • Lateral CPu lesions did not impair learning but favored spatial responses.
    • Medial CPu lesions impaired learning and favored cue responses, associated with increased thigmotaxis.
    • Fornix/fimbria lesions prevented spatial learning and favored cue responses.

    Conclusions:

    • The lateral and medial CPu have dissociable functions in spatial and cue-based learning.
    • The hippocampus and medial CPu may form a system supporting cognitive-spatial information processing.
    • These findings highlight the neural basis of competing response tendencies in spatial navigation.