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Dealing with energy demand: the AMP-activated protein kinase
B E Kemp1, K I Mitchelhill, D Stapleton
1St Vincent's Institute of Medical Research, Fitzroy, Victoria. b.kemp@medicine.unimelb.edu.au
Trends in Biochemical Sciences
|March 24, 1999
Abstract:
The AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise, nutrient starvation and ischemia/hypoxia, and modulates many aspects of mammalian cell metabolism. The AMPK yeast homolog, Snf1p, plays a major role in adaption to glucose deprivation. In mammals, AMPK also has diverse roles that extend from energy metabolism through to transcriptional control.