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Shock wave-inertial microbubble interaction: methodology, physical characterization, and bioeffect study.

P Zhong1, H Lin, X Xi

  • 1Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina 27708, USA. pzl@mel.egr.duke.edu

The Journal of the Acoustical Society of America
|March 25, 1999
PubMed
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A modified lithotripter creates shock wave-microbubble interactions to enhance cell permeability or tissue destruction. This method precisely controls shock waves for targeted medical applications, improving macromolecule delivery and cell injury.

Area of Science:

  • Biomedical Engineering
  • Acoustic Physics
  • Cell Biology

Background:

  • Electrohydraulic shock wave lithotripsy (EHL) is a non-invasive treatment.
  • Modifying EHL devices can create novel therapeutic or diagnostic applications.
  • Controlling shock wave interactions with microbubbles is key to new biomedical applications.

Purpose of the Study:

  • To develop and test a modified electrohydraulic shock wave lithotripter for in situ shock wave-inertial microbubble interaction.
  • To investigate the adjustable parameters of the preceding weak shock wave.
  • To evaluate the effects of shock wave-microbubble interaction on cell permeability and injury.

Main Methods:

  • Fabrication of a modified annular ellipsoidal reflector for a Dornier XL-1 lithotripter.

Related Experiment Videos

  • Generation of a preceding weak shock wave using the modified reflector.
  • Characterization of microbubble dynamics and secondary shock wave emission using PVDF hydrophone, high-speed imaging, and passive cavitation detection.
  • Assessment of mouse lymphoid cell injury and membrane permeabilization.

    • Main Results:

    • The modified reflector generated a preceding weak shock wave adjustable from -0.96 to -1.91 MPa.
    • This shock wave induced inertial microbubbles that expanded and collapsed.
    • Strong secondary shock wave emission and microjet formation were observed.
    • Cell injury increased significantly at high exposure, while membrane permeabilization efficiency reached 91% at low exposure.

    Conclusions:

    • Shock wave-inertial microbubble interaction can be precisely controlled using a modified lithotripter.
    • The interaction can be selectively applied to enhance macromolecule delivery or induce tissue destruction.
    • This technology holds promise for targeted therapeutic applications in medicine.