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Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis
M H Chen1, M G Steiner, S E de Laszlo
1Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA.
Bioorganic & Medicinal Chemistry Letters
|March 26, 1999
Abstract:
A series of carbohydroxamido-oxazolidine inhibitors of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase, the enzyme responsible for the second step in lipid A biosynthesis, was identified. The most potent analog L-161,240 showed an IC50 = 30 nM in the DEACET assay and displayed an MIC of 1-3 microg/mL against wild-type E. coli.