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New lead compounds for brassinosteroid biosynthesis inhibitors
1The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama, Japan.
Bioorganic & Medicinal Chemistry Letters
|March 26, 1999
Abstract:
The first brassinosteroid biosynthesis inhibitor is reported. Among newly synthesized triazole derivatives, 4-(4-chlorophenyl)-2-phenyl-3-(1,2,4-triazoyl)butan-2-ol (6) was found to inhibit the growth of cress seedlings, and this inhibition was recovered by the treatment of brassinolide, suggesting that compound 6 primarily inhibits brassinosteroid biosynthesis.