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Related Experiment Videos

Headache in children with centrotemporal spikes.

D Melchionda1, A Verrotti, F Chiarelli

  • 1Department of Neurology, University of Chieti, Italy.

Neurophysiologie Clinique = Clinical Neurophysiology
|March 27, 1999
PubMed
Summary

Centrotemporal spikes (CTS) in children with headaches are not exclusive to epilepsy. Headache frequency correlates with CTS, suggesting a link between these neurological events.

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Area of Science:

  • Neurology
  • Pediatrics
  • Clinical Neurophysiology

Background:

  • Headache is a common symptom in childhood.
  • Rolandic centrotemporal spikes (CTS) are typically associated with benign childhood epilepsy.

Purpose of the Study:

  • To investigate the long-term evolution of headache in children with electroencephalogram (EEG) confirmed CTS.
  • To determine the relationship between CTS and headache frequency over time.

Main Methods:

  • A cohort of 32 children with headache and CTS was compared to 52 age- and sex-matched controls with headache but no EEG abnormalities.
  • Patients were followed for 5 years, monitoring headache frequency and EEG patterns.
  • Statistical analysis assessed the correlation between CTS and headache attacks.

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Main Results:

  • Headache frequency decreased in most children, similar to controls.
  • A significant positive correlation was found between CTS and headache frequency at baseline (r = 0.58) and follow-up (r = 0.64).
  • Increased headache frequency in 12.5% of patients was associated with higher CTS frequency; two patients showed EEG pattern changes.

Conclusions:

  • CTS are not pathognomonic for centrotemporal epilepsy in children presenting with headaches.
  • The evolution of CTS and headache frequency in children are statistically related, indicating a potential neurophysiological link beyond epilepsy.