Related Experiment Videos
Efficient synthesis of N-4 alkyl derivatives of 2',3'-dideoxycytidine (ddC)
E Dechaux1, R Pontikis, C Monneret
1Institut Curie, Section Recherche, UMR 176 CNRS-IC, Paris, France.
Nucleosides & Nucleotides
|March 27, 1999
Abstract:
The C-4 triisopropylphenylsulfonyl (TPS) group of the 2,3-dideoxyuridine derivative 2 is readily displaced in situ by nitrogen nucleophiles forming N-4 substituted ddC in acceptable yields.