Determination of the entrapped volume of liposomes: dilution method
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Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes
Published on: July 30, 2020
K Kawakami1, Y Nishihara, K Hirano
1Formulation R & D Laboratories, Shionogi & Co., Ltd., 12-4 Sagisu 5-chome, Fukushima-ku, Osaka, 553-0002, Japan. kohsaku.kawakami@shionogi.co.jp
Analytical Biochemistry
|March 30, 1999
Abstract:
A novel method was developed for the determination of the entrapped volume of liposomes. The obtained values of the entrapped volume by our "dilution method" agreed very well with those of the conventional "quenching method." The dilution method also offered the great advantages of simple procedure and high reproducibility. The principle and validity of our method are discussed.
