Liposarcoma: an update

Liposarcoma is one of the most common adult soft tissue sarcomas. It is best viewed as several related tumors rather than a common one, however. Support for this is derived from the fact that the various subtypes differ in their demographic, cytogenetic, and biologic properties. The pathologist, therefore, assumes a pivotal role in accurately classifying these lesions since this directly translates into grade and behavior. As the molecular events leading to these tumors are better understood, our approach to treating the various forms of liposarcoma may, likewise, differ.