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[Cutaneous-lymph node Kikuchi-Fujimoto disease].

C Letawe1, C Piérard-Franchimont, K A Rustom

  • 1Service de Dermatopathologie, CHU du Sart Tilman, Liège, Belgique.

Annales De Dermatologie Et De Venereologie
|March 30, 1999
PubMed
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Kikuchi-Fujimoto disease, a rare condition affecting lymph nodes and skin, was identified in a Yemeni man. This case highlights distinct features differentiating it from lupus erythematosus.

Area of Science:

  • Dermatology
  • Pathology
  • Immunology

Background:

  • Kikuchi-Fujimoto disease (KFD) is a rare, idiopathic condition characterized by necrotizing histiocytic lymphadenitis, first described in 1972.
  • KFD can manifest with cutaneous involvement, presenting diagnostic challenges.
  • This report details a case of KFD with concurrent skin and lymph node presentation.

Observation:

  • A Yemeni male presented with cervical lymphadenitis and facial papulo-nodular lesions.
  • Histopathological examination revealed necrotizing lymphadenitis with blast cells and absence of neutrophils.
  • Cutaneous lesions showed angiocentric mononuclear cell infiltration, including plasmacytoid cells and caryorrhexis.

Findings:

  • The case exhibited features overlapping with lupus erythematosus but possessed distinct characteristics.

Related Experiment Videos

  • Histologic findings of necrotizing lymphadenitis and specific cutaneous infiltrates were key diagnostic indicators.
  • Spontaneous resolution of symptoms occurred within three months.

    • Implications:

    • Accurate diagnosis of KFD is crucial, distinguishing it from autoimmune conditions like lupus erythematosus.
    • Understanding the distinct clinical and histological features aids in appropriate patient management.
    • Further research into the pathogenesis and long-term outcomes of KFD is warranted.