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[Toxic dermatitis caused by tramadol].

P D Ghislain1, T Wiart, N Bouhassoun

  • 1Service de Dermatologie, Centre Hospitalier Saint-Philibert, Université Catholique de Lille.

Annales De Dermatologie Et De Venereologie
|March 30, 1999
PubMed
Summary
This summary is machine-generated.

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Tramadol can cause severe skin reactions, including maculopapular eruptions and secondary erythrodermia. Early withdrawal of tramadol is crucial for managing these adverse drug events.

Area of Science:

  • Dermatology
  • Pharmacology
  • Toxicology

Background:

  • Tramadol hydrochloride (Topalgic) is a potent analgesic with rapidly expanding use.
  • Adverse skin reactions to tramadol are infrequently reported and typically benign.

Observation:

  • A 47-year-old male developed a pruritic maculopapular rash, hyperthermia, and systemic illness within four days of initiating tramadol for lower back pain.
  • The patient experienced secondary erythrodermia after corticosteroid treatment was discontinued, with complete resolution following tramadol withdrawal.

Findings:

  • This case highlights a severe, rapid-onset maculopapular toxic skin reaction to tramadol.
  • The reaction's development despite the absence of other medications suggests a direct tramadol effect or cross-reactivity.

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Implications:

  • Clinicians should be vigilant for severe cutaneous adverse drug reactions to tramadol, even with short-term use.
  • Prompt recognition and discontinuation of tramadol are essential for managing these reactions and preventing complications like erythrodermia.