Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA-protein cooperative binding through variable-range elastic coupling.

J Rudnick1, R Bruinsma

  • 1Department of Physics, University of California at Los Angeles, Los Angeles, California 90095-1547, USA. jrudnick@physics.ucla.edu

Biophysical Journal
|March 30, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Smectic viral capsids and the aneurysm instability.

Journal of physics. Condensed matter : an Institute of Physics journal·2018
Same author

Useful scars: Physics of the capsids of archaeal viruses.

Physical review. E·2016
Same author

A phase II study of bevacizumab and erlotinib after radiation and temozolomide in MGMT unmethylated GBM patients.

Journal of neuro-oncology·2015
Same author

Statistical Physics of Viral Capsids with Broken Symmetry.

Physical review letters·2015
Same author

Elasticity theory of macromolecular aggregates.

Physical review letters·2012
Same author

Evaluation of two different epidural catheters in clinical practice. narrowing down the incidence of paresthesia!

Acta anaesthesiologica Belgica·2007
Same journal

Quantifying the Peripheral Surface Information Entropy from Conformational Ensembles of Globular Protein-Peptide Complexes.

Biophysical journal·2026
Same journal

Anisotropic unbinding and location-dependent hovering of a kinesin motor head over microtubule.

Biophysical journal·2026
Same journal

Kinesin-5/Cut7 C-terminal tail phosphorylation influence on motor regulation through multi-scale molecular modeling.

Biophysical journal·2026
Same journal

Dynamic conformations of fluorophores on self-labeling protein tags.

Biophysical journal·2026
Same journal

Different actions of RyR2 open and closed channel block explained by a multiscale Ca<sup>2+</sup> release model.

Biophysical journal·2026
Same journal

Membrane Environment Sets the Functional pK<sub>a</sub> of Ionizable Lipids.

Biophysical journal·2026
See all related articles

This study proposes a new model for protein cooperativity on DNA, where tension influences interactions between DNA-bound proteins. This tension-mediated mechanism explains how proteins can interact without direct contact, impacting DNA-protein binding dynamics.

Area of Science:

  • Molecular Biology
  • Biophysics
  • Genetics

Background:

  • Protein-DNA interactions are crucial for biological processes.
  • Cooperativity in protein binding influences gene regulation and DNA dynamics.
  • Understanding the mechanisms of protein-protein interactions on DNA is essential.

Purpose of the Study:

  • To propose a novel mechanism for cooperativity between proteins bound to DNA.
  • To model tension-mediated interactions between non-contacting DNA-bound proteins.
  • To investigate how DNA deformation and altered mechanical properties contribute to protein cooperativity.

Main Methods:

  • Modeling DNA as a two-dimensional worm-like chain.
  • Simulating the effects of protein binding on DNA bending and bending modulus.

Related Experiment Videos

  • Analyzing tension-controlled protein-protein interactions, including attractive and repulsive forces.

    • Main Results:

    • A simple model for tension-mediated cooperativity between DNA-bound proteins is presented.
    • Protein binding introduces DNA bends and modifies DNA's bending modulus, mediating interactions.
    • Applied tension controls the strength and range of these protein-protein interactions.

    Conclusions:

    • The proposed model offers a biophysical explanation for cooperativity in protein-DNA binding.
    • Tension-mediated interactions can occur between proteins without direct physical contact.
    • The findings have implications for understanding gene regulation and designing experimental approaches.