Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multineuronal spike classification based on multisite electrode recording, whole-waveform analysis, and hierarchical

H Kaneko1, S S Suzuki, J Okada

  • 1National Institute of Bioscience and Human-Technology, Ibaraki, Japan. kaneko@nibh.go.jp

IEEE Transactions on Bio-Medical Engineering
|March 31, 1999
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular basis of selective IgG2 deficiency. The mutated membrane-bound form of gamma2 heavy chain caused complete IGG2 deficiency in two Japanese siblings.

The Journal of clinical investigation·1998
Same author

Spatial limitation of vertical-size disparity processing.

Vision research·1998
Same author

Cloning and functional analysis of rat cyclin D2 promoter: multiple prolactin-responsive elements.

Biochemistry and molecular biology international·1998
Same author

Novel exonic mutation (5319 G to A) resulting in two aberrantly spliced transcripts of the ATM gene in a Japanese patient with ataxia-telangiectasia.

Human mutation·1998
Same author

Ovarian response and FSH profile in cows following injection of various doses of inhibin antiserum.

The Journal of veterinary medical science·1998
Same author

Direct measurement of the chloride concentration in newt olfactory receptors with the fluorescent probe.

Neuroscience letters·1997

We developed a new method to classify neuronal spikes using multisite electrode recordings and hierarchical clustering. This technique accurately separates the activity of adjacent neurons, even with overlapping spikes.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Signal Processing

Background:

  • Studying correlated activities of adjacent neurons is crucial for understanding nervous system function.
  • Conventional methods struggle to accurately classify spikes from nearby neurons, especially with overlapping signals.

Purpose of the Study:

  • To develop and validate a novel method for multineuronal spike classification.
  • To improve the separation of neuronal activity from adjacent neurons using multisite electrode recordings.

Main Methods:

  • Multineuronal spikes recorded using multisite electrodes in rat hippocampus.
  • Whole-waveform analysis and hierarchical clustering of spike damping factors.
  • Error minimization techniques for overlapping spikes and complex spike bursts.

Related Experiment Videos

Main Results:

  • The proposed method achieved better cluster separation compared to conventional techniques.
  • Automatic classification of multiple neuronal spikes with well-superimposed waveforms.
  • Successful separation of activities from adjacent neurons with overlapping spikes.

Conclusions:

  • The developed method effectively classifies multineuronal spikes from adjacent neurons.
  • This technique is particularly valuable for analyzing neural circuits with complex spike activity.
  • The approach offers improved accuracy for studying correlated neuronal activity.